A case of rhinocerebral mucormycosis with brain abscess drained by endoscopic endonasal skull base surgery

Kensuke Uraguchi; Kenichi Kozakura; Satoshi Oka; Takaya Higaki; Seiichiro Makihara; Toshi Imai; Akira Doi; Tsuyoshi Ohta; Shin Kariya; Kazunori Nishizaki

doi:10.1016/j.mmcr.2020.09.004

A case of rhinocerebral mucormycosis with brain abscess drained by endoscopic endonasal skull base surgery

Med Mycol Case Rep. 2020 Sep 25:30:22-25. doi: 10.1016/j.mmcr.2020.09.004. eCollection 2020 Dec.

Authors

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
² Department of Otorhinolaryngology, Kochi Health Sciences Center, Kochi, Japan.
³ Department of Hematology and Blood Transfusion, Kochi Health Sciences Center, Kochi, Japan.
⁴ Department of Otorhinolaryngology, Head and Neck Surgery, Kagawa Rosai Hospital, Kagawa, Japan.
⁵ Department of Neurosurgery, Kochi Health Sciences Center, Kochi, Japan.

Abstract

A 70-year-old Japanese man undergoing remission induction therapy for acute monocytic leukemia (AML-M5b) developed fever and headache, and was started on antibiotics and liposomal amphotericin B (L-AMB). There was no improvement, and computed tomography and contrast-enhanced magnetic resonance imaging revealed acute rhinosinusitis and brain abscess. Successful endoscopic endonasal surgery was performed at this point, providing drainage for the rhinosinusitis and abscess. Histopathological findings showed the mucormycosis.

Keywords: Acute monocytic leukemia; Acute rhinosinusitis; Brain abscess; Endoscopic endonasal skull base surgery; Rhinocerebral mucormycosis.

Publication types

Case Reports