Corynebacterium diphtheriae Infection in Mahajanga, Madagascar: First Case Report

J Trop Pediatr. 2021 Jan 29;67(1):fmaa064. doi: 10.1093/tropej/fmaa064.

Abstract

Diphtheria is an infection that has been unreported for more than two decades in Mahajanga. A child, aged 4, presented with a pseudomembranous pharyngitis was associated with a dysphagia. He was from a rural municipality of Ambato Boeny at Mahajanga province and was admitted to the Pediatric Unit of the University Hospital Center. The child was not immunized against diphtheria. A throat swab was performed and cultured, from which Corynebacterium diphtheriae was identified. The strain, of biovar Mitis, was confirmed as diphtheria toxin (DT)-gene positive and produced DT (Elek test). Unfortunately, the child developed cardiac and neurological complications and died of respiratory and heart failure.

Keywords: Corynebacterium diphtheriae; diphtheria toxin; pharyngitis.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Child, Preschool
  • Corynebacterium diphtheriae* / genetics
  • Diphtheria* / diagnosis
  • Family
  • Humans
  • Madagascar
  • Male
  • Pharyngitis*