Age is in the Eye of the Beholder: Distinguishing Molecular Signatures in Early-onset Pancreatic Adenocarcinomas

Emil Lou

doi:10.1158/1078-0432.CCR-20-3683

Age is in the Eye of the Beholder: Distinguishing Molecular Signatures in Early-onset Pancreatic Adenocarcinomas

Clin Cancer Res. 2021 Jan 1;27(1):8-10. doi: 10.1158/1078-0432.CCR-20-3683. Epub 2020 Oct 27.

Author

Emil Lou¹

Affiliation

¹ Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota. [email protected].

PMID: 33109735
DOI: 10.1158/1078-0432.CCR-20-3683

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is more prevalent in older patients, but early-onset cases (<55 years) may be a distinct genetic subpopulation. Differential expression of CDKN2A and transcription factor FOXC2 were found in early-onset cases. This finding opens the door to investigating additional features that distinguish PDAC tumors in this age group.See related article by Tsang et al., p. 246.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adenocarcinoma* / diagnosis
Adenocarcinoma* / genetics
Aged
Carcinoma, Pancreatic Ductal* / diagnosis
Carcinoma, Pancreatic Ductal* / genetics
Humans
Pancreatic Ducts
Pancreatic Neoplasms* / diagnosis
Pancreatic Neoplasms* / genetics