Correlates of diabetic polyneuropathy of the elderly in Sub-Saharan Africa

PLoS One. 2020 Oct 29;15(10):e0240602. doi: 10.1371/journal.pone.0240602. eCollection 2020.

Abstract

Background: Diabetic polyneuropathy is associated with significant physical disability among older adults. However, their frequency and correlates are not well known in the older adults in Sub-Saharan-Africa. The objectives were to evaluate the hospital-based prevalence of diabetic polyneuropathy and identify its correlates in older adults.

Methods: Over a period of 5 months, a cross-sectional survey was carried out at Douala Laquintinie Hospital (DLH), a main reference hospital in Douala, the economic capital of Cameroon. Participants in our study group comprised all patients with type 2 diabetes, whatever the reason for their reporting to the hospital. Diabetic Polyneuropathy was defined according to a Diabetic Neuropathy Examination score > 3/16.

Results: A total of 159 older adults with diabetes were examined during this recruitment period, among whom 106 (66.7%) were women. The mean age was 68.3 ± 6.5 years. Diabetes median duration was 108 months. For all patients assessed using the Diabetic Neuropathy Examination score, polyneuropathy was reported in 31.4%; among them, polyneuropathy proved symptomatic in 78% of them. Correlates of polyneuropathy were glycated hemoglobin (p = 0.049), HIV infection (p = 0.031) and albuminuria (p< 0.001), even after adjustment for age, gender and duration of diabetes.

Conclusion: A third of older adults with diabetes who visited our hospital were diagnosed with prevalent diabetes-related polyneuropathy. It shows that early detection is required through routine screening and regular follow-up examinations in order to reduce the risk of disability and improve the quality of life in elderly diabetics.

MeSH terms

  • Africa South of the Sahara / epidemiology
  • Aged
  • Cameroon / epidemiology
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / pathology
  • Diabetic Neuropathies / blood
  • Diabetic Neuropathies / complications
  • Diabetic Neuropathies / epidemiology*
  • Diabetic Neuropathies / pathology
  • Female
  • Geriatric Assessment
  • Glycated Hemoglobin / metabolism
  • HIV Infections / blood
  • HIV Infections / complications
  • HIV Infections / epidemiology*
  • HIV Infections / pathology
  • Humans
  • Male
  • Middle Aged
  • Neuralgia / blood
  • Neuralgia / epidemiology*
  • Neuralgia / pathology
  • Quality of Life
  • Risk Factors

Substances

  • Glycated Hemoglobin A

Grants and funding

No funding received for this study.