Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1

Beatriz Sierra; Ana B Pérez; Eglis Aguirre; Claudia Bracho; Odalys Valdés; Narciso Jimenez; Waldemar Baldoquin; Guelsys Gonzalez; Lilia M Ortega; Maria C Montalvo; Sonia Resik; Delmis Alvarez; Maria G Guzmán

doi:10.1093/ofid/ofaa407

Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1

Open Forum Infect Dis. 2020 Sep 3;7(10):ofaa407. doi: 10.1093/ofid/ofaa407. eCollection 2020 Oct.

Authors

Affiliations

¹ Cellular Immunology Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
² Respiratory Viruses Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
³ Medical Attention Branch, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
⁴ Epidemiology Department Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
⁵ Intensive Care Unit, Medical Attention Branch, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
⁶ Hepatitis Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
⁷ Enterovirus Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
⁸ Department of Computing, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
⁹ Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.

Abstract

Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19's pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome.

Keywords: COVID-19; chemokines; cytokines; inflammation; prognostic biomarkers.