Abstract
Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.
MeSH terms
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Copper / chemistry
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HeLa Cells
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Humans
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Isotope Labeling
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Ligands
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Mass Spectrometry
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Metalloporphyrins / adverse effects
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Metalloporphyrins / chemistry*
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Optical Imaging
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Photochemotherapy
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Photosensitizing Agents / adverse effects
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Photosensitizing Agents / chemistry*
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Platinum / adverse effects
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Platinum / chemistry*
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Structure-Activity Relationship
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Tissue Distribution
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Zinc Isotopes / chemistry*
Substances
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Ligands
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Metalloporphyrins
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Photosensitizing Agents
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Zinc Isotopes
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Zinc-67
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Platinum
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Copper