A Tug-of-War Over Methionine

Cell Metab. 2020 Nov 3;32(5):699-701. doi: 10.1016/j.cmet.2020.10.016.

Abstract

Nutrient acquisition and metabolism are integral components of cell growth, proliferation, and differentiation programs. In a recent study in Nature, Bian et al. (2020) revealed that cancer cells outcompete T cells for methionine uptake, resulting in diminished SAM production, attenuated H3K79 dimethylation, decreased STAT5 expression, and impaired T cell immunity to cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Histones
  • Methionine* / metabolism
  • Methylation
  • Neoplasms*
  • S-Adenosylmethionine / metabolism
  • T-Lymphocytes / metabolism

Substances

  • Histones
  • S-Adenosylmethionine
  • Methionine