To explore the threshold effect of body mass index (BMI) on bone mineral density (BMD) in Chinese women living in the fluorosis area, we conducted a cross-sectional study and recruited 722 women in rural areas in Henan Province, China. After detection and analyses, we found that compared with the normal BMI group, the risk of osteoporosis in the overweight and obese groups were reduced by 32% and 69%, respectively. Threshold effect analysis showed that BMD was positively correlated with BMI when BMI was 16.8-31.2 kg/m2; while when BMI was greater than 31.2 kg/m2, the correlation reached saturation. The correlation observed between low-to-moderate fluoride exposure and BMD in rural women was not significant.
采用整群抽样的方法对豫东饮水型氟病区722名女性开展一项横断面调查，以探讨氟病区女性体重指数（BMI）与骨密度的关系及阈值效应。结果显示，与BMI正常组相比，超重组和肥胖组研究对象患骨质疏松的风险分别降低了32%和69%；氟病区女性骨密度与BMI之间存在阈值效应关系，BMI为（18.0~31.2）kg/m2时，骨密度T值与BMI呈正相关；BMI为（31.3~40.6）kg/m2，两者无关联相关性；未观察到低至中等程度氟暴露影响成年女性骨密度。.
Keywords: Body mass index; Bone density; Fluoride; Osteoporosis.