Trichloroethylene increases pulmonary endothelial permeability: implication for pulmonary veno-occlusive disease

Julien Caliez; Marianne Riou; Grégoire Manaud; Morad K Nakhleh; Marceau Quatredeniers; Catherine Rucker-Martin; Peter Dorfmüller; Florence Lecerf; Maria C Vinhas; Salam Khatib; Hossam Haick; Sylvia Cohen-Kaminsky; Marc Humbert; David Montani; Frédéric Perros

doi:10.1177/2045894020907884

Trichloroethylene increases pulmonary endothelial permeability: implication for pulmonary veno-occlusive disease

Pulm Circ. 2020 Oct 16;10(4):2045894020907884. doi: 10.1177/2045894020907884. eCollection 2020 Oct-Dec.

Authors

Julien Caliez^{1

2

3}, Marianne Riou^{1

2

3

4}, Grégoire Manaud^{1

2}, Morad K Nakhleh^{1

2}, Marceau Quatredeniers^{1

2}, Catherine Rucker-Martin^{1

2

5}, Peter Dorfmüller^{1

2

5}, Florence Lecerf^{2

5}, Maria C Vinhas^{2

5}, Salam Khatib⁶, Hossam Haick⁶, Sylvia Cohen-Kaminsky^{1

2}, Marc Humbert^{1

2

3}, David Montani^{1

2

3}, Frédéric Perros^{1

2}

Affiliations

¹ School of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
² INSERM UMR_S 999 "Pulmonary Hypertension: Pathophysiology and Novel Therapies", Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
³ Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
⁴ Pneumologie, Hopitaux universitaires de Strasbourg, Strasbourg, France.
⁵ Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France.
⁶ Département of Chemical Engineering and Russel Berrie Nanotechnology Institute, Haifa, Israel.

Abstract

Trichloroethylene exposure is a major risk factor for pulmonary veno-occlusive disease. We demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, through vascular endothelial (VE)-Cadherin internalisation, and suggested that this mechanism may play a role in the development of pulmonary veno-occlusive disease.

Keywords: endothelial permeability; pulmonary veno-occlusive disease; trichloroethylene.