1 Department of Cardiology, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, Upper Maudlin Street, Bristol BS2 8HW, UK.
2 Bristol Medical School, University of Bristol, 69 St. Michael's Hill, Bristol, BS2 8DZ, UK.
3 Bristol National Institute of Health Research (NIHR) Biomedical Research Centre, University Hospitals Bristol NHS Trust and University of Bristol, Bristol, BS2 8HW, UK.