Is COVID-19 a Perfect Storm for Parkinson's Disease?

Patrik Brundin; Avindra Nath; J David Beckham

doi:10.1016/j.tins.2020.10.009

Is COVID-19 a Perfect Storm for Parkinson's Disease?

Trends Neurosci. 2020 Dec;43(12):931-933. doi: 10.1016/j.tins.2020.10.009. Epub 2020 Oct 21.

Authors

Patrik Brundin¹, Avindra Nath², J David Beckham³

Affiliations

¹ Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA. Electronic address: [email protected].
² Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
³ Division of Medicine, Neurology and Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Abstract

Three recent case reports (by Méndez-Guerrero et al.,Cohen et al., and Faber et al.) describe the development of acute parkinsonism following coronavirus disease 2019 (COVID-19). We discuss possible underlying cellular and molecular mechanisms, and whether COVID-19 might be associated with elevated long-term risk of Parkinson's disease (PD).

Keywords: SARS-CoV-2; alpha-synuclein; dopamine; neurodegeneration; neuroinflammation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

COVID-19 / complications*
COVID-19 / pathology
COVID-19 / physiopathology
Humans
Parkinson Disease / virology*
SARS-CoV-2