Research Progress on circRNA in Nervous System Diseases

Curr Alzheimer Res. 2020;17(8):687-697. doi: 10.2174/1567205017666201111114928.

Abstract

Circular RNAs (circRNAs) are a kind of non-coding RNA molecule with highly stable circular structures. CircRNAs are primarily composed of exons and/or introns. Recently, a lot of exciting studies showed that circRNA played an essential role in the development of nervous system diseases. Here, classification, characteristics, biogenesis, and the association of circRNA dysregulation with nervous system diseases, such as Alzheimer's disease, are summarized. The review not only contributes to a better understanding of circRNAs, but also provides new research directions toward the diagnosis, treatment, and prevention of nervous system diseases.

Keywords: Alzheimer's disease; Circular RNA; Parkinson disease; disease; nervous system; non-coding RNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / etiology
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism
  • Brain / metabolism
  • Cell-Free Nucleic Acids / metabolism*
  • Humans
  • Nervous System Diseases / etiology
  • Nervous System Diseases / genetics
  • Nervous System Diseases / metabolism*

Substances

  • Cell-Free Nucleic Acids