Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research

Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe₃O₄-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe₃O₄ and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe₃O₄-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe₃O₄-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.