Abstract
We analysed factors associated with neutralising antibody levels in 330 convalescent plasma donors. Women and younger donors were more likely not to have measurable neutralising antibodies, while higher antibody levels were observed in men, in older donors and in those who had been hospitalised. These data will be of value in the timely recruitment of convalescent plasma donors most likely to have high levels of neutralising antibodies for ongoing studies investigating its effectiveness.
Keywords:
COVID-19; SARS-CoV-2; convalescent plasma; multivariable model; neutralising antibody levels; plasma donor.
MeSH terms
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Age Factors
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Aged
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Antibodies, Neutralizing / blood*
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Antibodies, Neutralizing / therapeutic use
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Antibodies, Viral / blood*
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Betacoronavirus / immunology*
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Blood Donors* / statistics & numerical data
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COVID-19
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COVID-19 Serotherapy
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Coronavirus Infections / blood*
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Coronavirus Infections / diagnosis
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Coronavirus Infections / immunology
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Coronavirus Infections / therapy*
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England
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Enzyme-Linked Immunosorbent Assay
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Hospitalization*
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Humans
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Immunization, Passive
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Male
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Pandemics
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Pneumonia, Viral / blood*
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Pneumonia, Viral / diagnosis
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Pneumonia, Viral / immunology
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Pneumonia, Viral / therapy*
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SARS-CoV-2
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Sex Factors
Substances
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Antibodies, Neutralizing
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Antibodies, Viral