Diterpenoid alkaloids from Aconitum barbatum var. puberulum Ledeb

Nurfida Ablajan; Bo Zhao; Jiang-Yu Zhao; Bian-Lin Wang; Sh Sh Sagdullaev; H A Aisa

doi:10.1016/j.phytochem.2020.112567

Diterpenoid alkaloids from Aconitum barbatum var. puberulum Ledeb

Phytochemistry. 2021 Jan:181:112567. doi: 10.1016/j.phytochem.2020.112567. Epub 2020 Nov 13.

Authors

Nurfida Ablajan¹, Bo Zhao², Jiang-Yu Zhao², Bian-Lin Wang², Sh Sh Sagdullaev³, H A Aisa⁴

Affiliations

¹ State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi, 830011, Xinjiang, PR China; University of Chinese Academy of Sciences, Beijing, 100039, PR China.
² State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi, 830011, Xinjiang, PR China.
³ S.Yu.Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
⁴ State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi, 830011, Xinjiang, PR China. Electronic address: [email protected].

PMID: 33197742
DOI: 10.1016/j.phytochem.2020.112567

Abstract

Seven previously undescribed diterpenoid alkaloids, including five C₂₀-diterpenoid alkaloids, barpuberudine, barpubesines A-D, and two C₁₈-diterpenoid alkaloids, barpubenines A-B, along with 11 known diterpenoid alkaloids were isolated from the whole plant of Aconitum barbatum var. puberulum Ledeb. (Ranunculaceae). Barpuberudine is an unprecedented carbon skeleton of C₂₀-diterpenoid alkaloid, while barpubenines A-B are the first example of rearranged types in C₁₈-diterpenoid alkaloids. Their structures were elucidated based on a comprehensive spectroscopic data analysis. The probable pathway of biogenesis of barpuberudine and barpubenines A-B were discussed. Additionally, the antiarrhythmic, cytotoxic and antimicrobial activities of isolates were also evaluated.

Keywords: Aconitum barbatum var. puberulum Ledeb.; Barpubenines; Barpuberudine; Barpubesines; Biological activities; Diterpenoid alkaloids; Ranunculaceae.

MeSH terms

Aconitum*
Alkaloids* / pharmacology
Diterpenes / pharmacology
Molecular Structure
Plant Roots

Substances

Alkaloids
Diterpenes