Dihydroartemisinin loaded layered double hydroxide nanocomposites for tumor specific photothermal-chemodynamic therapy

Jingsong Lu; Zhenhu Guo; Shenglei Che; Fei Gao; Zi Gu; Jianzhong Xu; Yongjie Chi; Wanling Xu; Junxin Zhang; Nonaka Takuya; Jing Yu; Lingyun Zhao

doi:10.1039/d0tb01964j

Dihydroartemisinin loaded layered double hydroxide nanocomposites for tumor specific photothermal-chemodynamic therapy

J Mater Chem B. 2020 Dec 23;8(48):11082-11089. doi: 10.1039/d0tb01964j.

Authors

Jingsong Lu¹, Zhenhu Guo², Shenglei Che³, Fei Gao⁴, Zi Gu⁵, Jianzhong Xu⁴, Yongjie Chi⁶, Wanling Xu⁴, Junxin Zhang⁴, Nonaka Takuya⁴, Jing Yu³, Lingyun Zhao⁴

Affiliations

¹ Research Center of Magnetic and Electronic Materials, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China. [email protected] and State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China. [email protected] and Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
² State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China. [email protected] and Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China and State Key Laboratory of Powder Metallurgy, Powder Metallurgy Research Institute, Central South University, Changsha 410083, China.
³ Research Center of Magnetic and Electronic Materials, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China. [email protected].
⁴ State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China. [email protected] and Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
⁵ School of Chemical Engineering and Australian Centre for NanoMedicine (ACN), University of New South Wales, Australia.
⁶ State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China. [email protected] and Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China and School of Earth Science and Resources, China University of Geosciences (Beijing), Beijing, 100083, China.

PMID: 33206112
DOI: 10.1039/d0tb01964j

Abstract

With the inspiration to develop new cancer nanotherapeutics by repurposing old drugs, in the current study, a novel two dimensional nanomedicine namely Mn doped, dihydroartemisinin (DHA) loaded layered double hydroxide (MnMgFe-LDH/DHA) with peroxide self-supplying properties for enhanced photothermal-chemodynamic therapy was proposed. Such nanostructures could be synthesized by a simple coprecipitation method, and the as-prepared MnMgFe-LDH/DHA exhibits excellent photothermal properties with a photothermal conversion efficiency up to 10.7%. Besides, the in situ reaction between the released DHA and Fe2+/Mn2+ produced by the degradation of LDH can lead to a burst of intracellular reactive oxygen species (ROS) by Fenton-like reactions. Furthermore, the in vivo experiments demonstrate that MnMgFe-LDH/DHA exhibits a remarkable chemodynamic/photothermal therapy (CDT/PTT) synergistic effect on tumor treatment with negligible damage to normal tissues. Finally, this research provides a smart strategy to construct a DHA repurposing nanomedicine for tumor specific treatment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / administration & dosage
Antineoplastic Agents / chemical synthesis*
Artemisinins / administration & dosage
Artemisinins / chemical synthesis*
Cell Line, Tumor
Female
Hydroxides / administration & dosage
Hydroxides / chemical synthesis*
Mice
Mice, Inbred BALB C
Nanocomposites / administration & dosage
Nanocomposites / chemistry*
Neoplasms / drug therapy
Neoplasms / pathology
Photosensitizing Agents / administration & dosage
Photosensitizing Agents / chemical synthesis*
Photothermal Therapy / methods*
Xenograft Model Antitumor Assays / methods

Substances

Antineoplastic Agents
Artemisinins
Hydroxides
Photosensitizing Agents
artenimol
hydroxide ion