Multi-institutional Survey of Squamous Cell Carcinoma of the External Auditory Canal in Japan

Kiyoto Shiga; Ken-Ichi Nibu; Yasushi Fujimoto; Takahiro Asakage; Akihiro Homma; Hiroki Mitani; Takenori Ogawa; Kenji Okami; Shigeyuki Murono; Shigeru Hirano; Tsutomu Ueda; Nobuhiro Hanai; Kiyoaki Tsukahara; Ichiro Ota; Seiichi Yoshimoto; Takeshi Shinozaki; Shigemichi Iwae; Katsunori Katagiri; Daisuke Saito; Naomi Kiyota; Makoto Tahara; Fumiaki Takahashi; Ryuichi Hayashi

doi:10.1002/lary.28936

Multi-institutional Survey of Squamous Cell Carcinoma of the External Auditory Canal in Japan

Laryngoscope. 2021 Mar;131(3):E870-E874. doi: 10.1002/lary.28936. Epub 2020 Jul 30.

Authors

Kiyoto Shiga¹, Ken-Ichi Nibu², Yasushi Fujimoto³, Takahiro Asakage⁴, Akihiro Homma⁵, Hiroki Mitani⁶, Takenori Ogawa⁷, Kenji Okami⁸, Shigeyuki Murono⁹, Shigeru Hirano¹⁰, Tsutomu Ueda¹¹, Nobuhiro Hanai¹², Kiyoaki Tsukahara¹³, Ichiro Ota¹⁴, Seiichi Yoshimoto¹⁵, Takeshi Shinozaki¹⁶, Shigemichi Iwae¹⁷, Katsunori Katagiri¹, Daisuke Saito¹, Naomi Kiyota¹⁸, Makoto Tahara¹⁹, Fumiaki Takahashi²⁰, Ryuichi Hayashi¹⁶

Affiliations

¹ Department of Head and Neck Surgery, Iwate Medical University School of Medicine, Yahaba, Japan.
² Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
³ Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
⁴ Department of Head and Neck Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Japan.
⁵ Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
⁶ Department of Head and Neck Surgery, Cancer Institute Hospital of JFCR, Tokyo, Japan.
⁷ Department of Otolaryngology-Head and Neck Surgery, Tohoku University Hospital, Sendai, Japan.
⁸ Department of Otolaryngology, Tokai University School of Medicine, Hiratsuka, Japan.
⁹ Department of Otolaryngology, Fukushima Medical University, Fukushima, Japan.
¹⁰ Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
¹¹ Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Higashihiroshima, Japan.
¹² Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
¹³ Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Shinjuku-ku, Japan.
¹⁴ Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Japan.
¹⁵ Department of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
¹⁶ Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
¹⁷ Department of Head and Neck Surgery, Hyogo Cancer Center, Akashi, Japan.
¹⁸ Department of Medical Oncology/Hematology, Kobe University Hospital Cancer Center, Kobe, Japan.
¹⁹ Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
²⁰ Division of Medical Engineering, Department of Information Science, Iwate Medical University, Yahaba, Japan.

PMID: 33216374
DOI: 10.1002/lary.28936

Abstract

Objectives: This study aimed to evaluate the efficacy of chemoradiotherapy (CRT) for patients with advanced cancer of the external auditory canal (EAC) by analyzing the outcome of the patients.

Methods: This is a multi-institutional retrospective survey, and we reviewed the medical records of the subjects. A total of 181 patients with tumor (T)3 or T4 tumor in 17 institutions were enrolled. Further analysis was performed for 74 patients who underwent CRT under curative intent.

Results: Overall 5-year survival rates of the patients who underwent CRT (n = 74) were 54.6%. Those of the patients who underwent CRT with modified TPF (docetaxel, cisplatin [CDDP], and 5-fluorouracil) regimen (n = 50) and CRT with CDDP regimens (n = 24) were 64.4% and 36.7%, respectively. Significant differences were observed between these two groups.

Conclusion: Given the tendency that head and neck surgeons prefer CRT for advanced larger cancer of the EAC, CRT for advanced EAC cancer using the modified TPF regimen showed good clinical outcomes.

Level of evidence: 4 Laryngoscope, 131:E870-E874, 2021.

Keywords: Squamous cell carcinoma, external auditory canal, chemoradiotherapy, multi-institutional study.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Combined Chemotherapy Protocols*
Carcinoma, Squamous Cell / mortality
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / therapy*
Chemoradiotherapy*
Ear Canal*
Ear Neoplasms / mortality
Ear Neoplasms / pathology
Ear Neoplasms / therapy*
Humans
Japan
Practice Patterns, Physicians'*
Retrospective Studies
Surveys and Questionnaires
Survival Rate
Treatment Outcome