RETRACTED: MicroRNA-29a-3p strengthens the effect of dexmedetomidine on improving neurologic damage in newborn rats with hypoxic-ischemic brain damage by inhibiting HDAC4

Brain Res Bull. 2021 Feb:167:71-79. doi: 10.1016/j.brainresbull.2020.11.011. Epub 2020 Nov 21.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figs. 2B+E, which appear to have the same eyebrow shaped phenotype as many other publications tabulated here (https://docs.google.com/spreadsheets/d/149EjFXVxpwkBXYJOnOHb6RhAqT4a2llhj9LM60MBffM/edit#gid=0). The journal requested the corresponding author comment on these concerns and provide the raw data. However, the authors were not responsive to the request for comment. Since original data could not be provided, the overall validity of the results could not be confirmed. Therefore, the Editor-in-Chief decided to retract the article.

Keywords: Apoptosis; Dexmedetomidine; Histone deacetylase 4; Hypoxic ischemic brain damage; MicroRNA-29a-3p; Neurological function.

Publication types

  • Retracted Publication

MeSH terms

  • Adrenergic alpha-2 Receptor Agonists / pharmacology*
  • Animals
  • Animals, Newborn
  • Dexmedetomidine / pharmacology*
  • Gene Expression Regulation / drug effects
  • Histone Deacetylases / drug effects
  • Histone Deacetylases / metabolism*
  • Hypoxia-Ischemia, Brain / metabolism
  • Hypoxia-Ischemia, Brain / pathology*
  • Male
  • MicroRNAs / metabolism*
  • MicroRNAs / pharmacology
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Adrenergic alpha-2 Receptor Agonists
  • MIRN29 microRNA, rat
  • MicroRNAs
  • Dexmedetomidine
  • HDAC4 protein, rat
  • Histone Deacetylases