Abstract
Hepatitis C virus (HCV) infection is very common in maintenance hemodialysis patients, causing high morbidity and mortality. This study aimed to evaluate the effectiveness and adverse events of direct-acting antivirals (DAAs) in maintenance hemodialysis patients complicated with chronic hepatitis C in real-world clinical practice.In this retrospective observational study, hemodialysis patients with chronic hepatitis C infection in the Third Central Hospital of Tianjin outpatient were screened, and appropriate treatment plans were selected accordingly. Totally 25 patients diagnosed with chronic hepatitis C and treated with DAAs for 12 weeks or 24 weeks were included. The sustained virologic response (SVR) rate obtained 12 weeks post-treatment (SVR12) was evaluated. Laboratory indexes and adverse reactions during the treatment process were also assessed.A total of 25 cases met the eligibility criteria and provided informed consent. Except for 1 patient who discontinued the treatment due to gastrointestinal bleeding, the remaining 24 cases completed the treatment cycle with 100% rapid virologic response (RVR) and 100% SVR12, with no serious adverse reactions recorded.Maintenance hemodialysis patients complicated with chronic hepatitis C in Chinese real-world setting tolerate DAAs very well, with a viral response rate reaching 100%.
MeSH terms
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Alanine Transaminase
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Amides / administration & dosage
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Amides / adverse effects
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Antiviral Agents / administration & dosage*
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Antiviral Agents / adverse effects
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Aspartate Aminotransferases
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Benzofurans / administration & dosage
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Benzofurans / adverse effects
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Carbamates / administration & dosage
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Carbamates / adverse effects
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Cyclopropanes / administration & dosage
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Cyclopropanes / adverse effects
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Drug Therapy, Combination
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Female
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Genotype
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Hemoglobins / analysis
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Hepacivirus / genetics
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Hepatitis C, Chronic / complications
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Hepatitis C, Chronic / drug therapy*
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Humans
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Imidazoles / administration & dosage
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Imidazoles / adverse effects
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Isoquinolines / administration & dosage
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Isoquinolines / adverse effects
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Male
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Middle Aged
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Pyrrolidines
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Quinoxalines / administration & dosage
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Quinoxalines / adverse effects
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RNA, Viral / blood
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Renal Dialysis*
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Renal Insufficiency, Chronic / complications*
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Renal Insufficiency, Chronic / therapy
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Retrospective Studies
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Sofosbuvir / administration & dosage
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Sofosbuvir / adverse effects
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Sulfonamides / administration & dosage
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Sulfonamides / adverse effects
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Valine / analogs & derivatives
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Viral Load
Substances
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Amides
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Antiviral Agents
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Benzofurans
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Carbamates
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Cyclopropanes
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Hemoglobins
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Imidazoles
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Isoquinolines
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Pyrrolidines
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Quinoxalines
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RNA, Viral
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Sulfonamides
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grazoprevir
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elbasvir
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Aspartate Aminotransferases
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Alanine Transaminase
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Valine
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daclatasvir
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asunaprevir
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Sofosbuvir