RSK2 and ERα comrades-in-arms in homeostasis and transformation

Katarzyna A Ludwik; Deborah A Lannigan

doi:10.1080/23723556.2020.1825916

RSK2 and ERα comrades-in-arms in homeostasis and transformation

Mol Cell Oncol. 2020 Nov 1;7(6):1825916. doi: 10.1080/23723556.2020.1825916.

Authors

Katarzyna A Ludwik¹, Deborah A Lannigan^{1

2

3}

Affiliations

¹ Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN, USA.
² Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
³ Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.

Abstract

The physiological response to estrogen differs according to the developmental stage. We show, in the adult, estrogen-responsiveness is driven by ERK1/2 (extracellular signal-regulated kinase 1/2) whereas its downstream effector, RSK2 (p90 ribosomal S6 kinase 2), prevents continuous ERK1/2 activity through regulation of oxidative stress. Bioinformatic analysis revealed RSK2 association with breast cancer risk and oral contraceptives.

Keywords: ERK1/2; Estrogen; RSK2; breast cancer; estrous cycle; exogenous estrogens; oral contraceptives; p90 ribosomal S6 kinase; p90RSK2.

Abstract

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