Klebsiella pneumoniae C3 lipopolysaccharide mutants obtained by resistance to bacteriophage FC3-9

Ann Inst Pasteur Microbiol (1985). 1986 Jul-Aug;137B(1):29-36. doi: 10.1016/s0769-2609(86)80091-6.

Abstract

Bacteriophage FC3-9 is one of the several bacteriophages of Klebsiella pneumoniae C3 isolated in our laboratory. Mutants resistant to this bacteriophage were isolated and found to be devoid of lipopolysaccharide O antigen, modified in outer-membrane protein composition and sensitive to complement killing (serum-sensitive), unlike the wild-type strain. Serum-resistant mutants were isolated from these strains. They regained the lipopolysaccharide O antigen and the wild-type outer membrane protein composition and became sensitive to bacteriophage FC3-9.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Bacterial / analysis
  • Bacterial Outer Membrane Proteins / analysis
  • Bacteriophages / immunology*
  • Klebsiella pneumoniae / enzymology
  • Klebsiella pneumoniae / genetics*
  • Klebsiella pneumoniae / immunology
  • Lipopolysaccharides / genetics*
  • Lipopolysaccharides / immunology
  • Mutation*

Substances

  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Lipopolysaccharides