Chronic lymphocytic leukemias with trisomy 12 show a distinct DNA methylation profile linked to altered chromatin activation

Maria Tsagiopoulou; Vicente Chapaprieta; Martí Duran-Ferrer; Theodoros Moysiadis; Fotis Psomopoulos; Panagoula Kollia; Nikos Papakonstantinou; Elias Campo; Kostas Stamatopoulos; Jose I Martin-Subero

doi:10.3324/haematol.2019.240721

Chronic lymphocytic leukemias with trisomy 12 show a distinct DNA methylation profile linked to altered chromatin activation

Haematologica. 2020 Dec 1;105(12):2864-2867. doi: 10.3324/haematol.2019.240721.

Affiliations

¹ Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.
² Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Spain.
³ Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Chromatin
Chromosome Disorders*
Chromosomes, Human, Pair 12 / genetics
DNA Methylation
Humans
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Trisomy / genetics

Substances

Chromatin

Grants and funding

Funding: data used in the present study have been generated through funding from the European Union’s Seventh Framework Programme through the Blueprint Consortium (grant agreement 282510), the International Cancer Genome Consortium (Chronic Lymphocytic Leukemia Genome consortium to EC), the World Wide Cancer Research Foundation Grant No. 16–1285 (to JIM-S), the Generalitat de Catalunya Suport Grups de Recerca AGAUR 2017- SGR-736 (to JIM-S) and 2017-SGR-1142 (to EC), and CIBERONC (CB16/12/00225). EC is an Academia Researcher of the Institució Catalana de Recerca I Estudis Avançats (ICREA) of the Generalitat de Catalunya. MT is a recipient of a fellowship from the State Scholarships Foundation of Greece, and a short term collaboration award winner by the European Hematology Association.