Duration of Viral Clearance in Children With SARS-CoV-2 Infection in Rajasthan, India

Indian Pediatr. 2021 Feb 15;58(2):123-125. doi: 10.1007/s13312-021-2125-6. Epub 2020 Nov 29.

Abstract

Objective: To study the clinical and laboratory profile and to assess period for viral clearance in COVID 19 children.

Methods: We reviewed hospital records of children (<18 years) admitted from 1 April to 31 May, 2020 at a tertiary-care public hospital and identified those positive for severe acute respiratory syndrome corona virus (SARS-CoV-2) by RT-PCR of respiratory secretions.

Results: 81.2% of the 85 children studied were asymptomatic and 3 (8.5%) died. Severe lymphopenia (43.8%), raised C-reactive protein (93.8%), raised erythrocyte sedimentation rate (75%) and high (>500ng/mL) levels of D-dimer (37.5%) were common. Median (IQR) duration of viral shedding was 7 (5-10) days, with range of 2 to 45 days; 96.3% had viral clearance within 14 days.

Conclusions: Majority of children aged <18 years with SARS-CoV-2 infection had viral clearance within 14 days.

MeSH terms

  • Antibodies, Viral / blood
  • Blood Sedimentation
  • C-Reactive Protein / analysis
  • COVID-19 Testing / methods
  • COVID-19 Testing / statistics & numerical data
  • COVID-19* / blood
  • COVID-19* / epidemiology
  • COVID-19* / physiopathology
  • COVID-19* / therapy
  • Child
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis
  • Hospitalization / statistics & numerical data
  • Humans
  • India / epidemiology
  • Lymphocyte Count / methods
  • Male
  • SARS-CoV-2* / isolation & purification
  • SARS-CoV-2* / physiology
  • Virus Shedding

Substances

  • Antibodies, Viral
  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D
  • C-Reactive Protein