Advanced practice in nursing is well established and has been active since the 1800s. In most cases, the role was developed because of a specific need or gap in patient care. Advanced practice nurses (APNs) have been experts in medical aesthetic injections for more than 30 years. The APNs' independence became increasingly common as a mechanism of continuity of care for the non-surgical-medical aesthetic patients. The APN role has evolved, and nurse practitioners (NPs) are now collaborating with nurses safely and effectively in nurse-led clinics in medical aesthetics. There are specific education and college regulations that are required to ensure patient safety in this collaborative care model. The role of the NP in a nurse-led medical aesthetic clinic is an accepted and recognized independent practice role that creates an innovative and well-regulated approach to patient care.