Hypothalamic Ceramides and the Ovarian Sympathetic System: At the Crossroads of Obesity and Puberty

Maria I Stamou; Ravikumar Balasubramanian

doi:10.1016/j.cmet.2020.11.012

Hypothalamic Ceramides and the Ovarian Sympathetic System: At the Crossroads of Obesity and Puberty

Cell Metab. 2021 Jan 5;33(1):6-8. doi: 10.1016/j.cmet.2020.11.012. Epub 2020 Dec 1.

Authors

Maria I Stamou¹, Ravikumar Balasubramanian²

Affiliations

¹ Harvard MGH Center for Reproductive Medicine and Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
² Harvard MGH Center for Reproductive Medicine and Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: [email protected].

Abstract

Childhood obesity has been linked to early puberty in girls but the mechanism(s) by which overnutrition triggers pubertal onset remain unclear. In a recent issue of Cell Metabolism, Heras et al., 2020 implicate a non-canonical central ceramide to ovarian sympathetic innervation pathway as a novel mediator of obesity-induced pubertal acceleration in female rats.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Ceramides
Female
Hypothalamus
Obesity
Puberty
Puberty, Precocious*
Rats

Substances

Ceramides

Abstract

Publication types

MeSH terms

Substances

Grants and funding