NGS-based typings for 7 HLA loci in three populations from Rio de Janeiro, RJ, Brazil

Hum Immunol. 2021 Jan;82(1):3-4. doi: 10.1016/j.humimm.2020.11.003. Epub 2020 Nov 29.

Abstract

We investigated HLA class I (HLA-A, -B, and -C) and class II (HLA-DRB1, -DQB1, -DPA1, and -DPB1) alleles by NGS-based typing among 759 Brazilian individuals from three populations in the Rio de Janeiro city based on their self-declared skin color (Caucasian, N = 521, AFND-ID: 3730; Parda, N = 170, AFND-ID: 3728; Black, N = 68, AFND-ID: 3727) to calculate allelic and haplotypic frequencies, plus linkage disequilibrium. Only HLA-DRB1 locus deviated from Hardy-Weinberg equilibrium (in Caucasian and Black populations). The three populations shared the most frequent allele on HLA-A, -C, -DRB1, -DPA1, and -DPB1. Genotype and frequency data are available in the Allele Frequencies Net Database.

Keywords: Brazil; HLA; Next-generation sequencing; Population immunogenetics; Rio de Janeiro.

MeSH terms

  • Alleles
  • Brazil
  • Gene Frequency
  • Genetics, Population / statistics & numerical data
  • Haplotypes
  • High-Throughput Nucleotide Sequencing
  • Histocompatibility Antigens Class I / genetics*
  • Histocompatibility Antigens Class II / genetics*
  • Humans
  • Linkage Disequilibrium
  • Population Groups / genetics

Substances

  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II