Fetal teratogenicity in a rhesus macaque (Macaca mulatta): Association with the chronic maternal treatment of amitriptyline

Carissa E Hunter; Rachelle L Stammen; Terell Hamlet; Denise Bonenberger; Chunxia Li; Xiaodong Zhang; Fawn C Stroud; Anthony W S Chan

doi:10.1111/jmp.12499

Fetal teratogenicity in a rhesus macaque (Macaca mulatta): Association with the chronic maternal treatment of amitriptyline

J Med Primatol. 2021 Feb;50(1):75-78. doi: 10.1111/jmp.12499. Epub 2020 Dec 5.

Authors

Carissa E Hunter¹, Rachelle L Stammen², Terell Hamlet¹, Denise Bonenberger², Chunxia Li³, Xiaodong Zhang³, Fawn C Stroud², Anthony W S Chan^{1

4}

Affiliations

¹ Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
² Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
³ Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
⁴ Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.

PMID: 33277721
DOI: 10.1111/jmp.12499

Abstract

Amitriptyline is a tricyclic antidepressant commonly prescribed in humans for pain and sleep disorders and in non-human primates for self-injurious behaviors. Here, we report a clinical case on the teratogenic effect of maternal-fetal amitriptyline exposure.

Keywords: amitriptyline; non-human primates; self-injurious behavior; tricyclic antidepressant.

Publication types

Case Reports
Research Support, N.I.H., Extramural

MeSH terms

Amitriptyline / adverse effects*
Animals
Antidepressive Agents, Tricyclic / adverse effects*
Female
Macaca mulatta / abnormalities*
Maternal Exposure
Teratogenesis*
Teratogens*

Substances

Antidepressive Agents, Tricyclic
Teratogens
Amitriptyline

Grants and funding

OD010930/ORIP/NIH