Abstract
Here we review data suggestive of a role for RNA-binding proteins in vertebrate immunity. We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT1), DXO, LSM2, NELFE, PRRC2A (aka BAT2), and SKIV2L, encode RNA-binding proteins with clear roles in post-transcriptional gene regulation and RNA surveillance. These genes are likely to have important functions in immunity and are associated with autoimmune diseases.
Keywords:
RNA-binding proteins.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Gene Expression Regulation / genetics
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HLA Antigens / genetics
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HLA Antigens / metabolism
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Histocompatibility Antigens / genetics
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Histocompatibility Antigens / metabolism*
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Humans
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Immunity / genetics*
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Immunity / immunology
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Major Histocompatibility Complex / genetics
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Major Histocompatibility Complex / immunology
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism*
Substances
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HLA Antigens
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Histocompatibility Antigens
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RNA-Binding Proteins