A Window into Your Gut: Biologically Inspired Engineering of Mini-gut Tubes In Vitro

Magdalena Kasendra; James M Wells

doi:10.1016/j.devcel.2020.11.015

A Window into Your Gut: Biologically Inspired Engineering of Mini-gut Tubes In Vitro

Dev Cell. 2020 Dec 7;55(5):522-524. doi: 10.1016/j.devcel.2020.11.015.

Authors

Magdalena Kasendra¹, James M Wells²

Affiliations

¹ Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
² Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. Electronic address: [email protected].

PMID: 33290692
DOI: 10.1016/j.devcel.2020.11.015

Abstract

Recently in Nature, using biologically inspired design principles to recapitulate native crypt-villi topography and luminal flow, Nikolaev et al. engineered an intestinal organotypic culture system that is capable of long-term epithelial homeostasis. Mini-gut tubes were used in month-long studies of parasite-host interactions and completely regenerated following injury.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Gastrointestinal Microbiome*
Homeostasis
Intestinal Mucosa
Morphogenesis
Organoids*