Cascade Cyclizations of α,β-Unsaturated Thioesters: Additional Examples

J Org Chem. 2021 Jan 1;86(1):1191-1197. doi: 10.1021/acs.joc.0c02091. Epub 2020 Dec 13.

Abstract

Several additional examples of cascade cyclizations of α,β-unsaturated thioesters proceeding are reported, which proceed via two distinct mechanistic pathways: enantioselective acyl transfer promoted by amidine-based catalysts (ABCs) and a racemic chain mechanism mediated by a thiolate nucleophile.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't