Jekyll and Hyde: Activating the Hypoxic Translational Machinery

J J David Ho; Jonathan H Schatz; Jim Uniacke; Stephen Lee

doi:10.1016/j.tibs.2020.11.006

Jekyll and Hyde: Activating the Hypoxic Translational Machinery

Trends Biochem Sci. 2021 Mar;46(3):171-174. doi: 10.1016/j.tibs.2020.11.006. Epub 2020 Dec 9.

Authors

J J David Ho¹, Jonathan H Schatz¹, Jim Uniacke², Stephen Lee³

Affiliations

¹ Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Division of Hematology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
² Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
³ Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address: [email protected].

Abstract

Global translational remodeling has emerged as a principal mechanism of biological adaptation. Oxygen deficiency (hypoxia) disables the basal protein synthesis machinery ('Jekyll') and activates a hypoxic translational architecture ('Hyde') to drive translatome remodeling. Independent from mRNA-level fluctuations, this newer paradigm modernizes a field traditionally dominated by the hypoxia-inducible factor (HIF) transcriptional program.

Keywords: HIF; hypoxia; oxygen; protein synthesis; translation heterogeneity; translatome.

MeSH terms

Cell Hypoxia
Humans
Hypoxia*
Hypoxia-Inducible Factor 1, alpha Subunit
Oxygen
Protein Biosynthesis*
RNA, Messenger / metabolism

Substances

Hypoxia-Inducible Factor 1, alpha Subunit
RNA, Messenger
Oxygen

Abstract

MeSH terms

Substances

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