LncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children

Zhiyuan Wu; Yongqin Yu; Lanyan Fu; Hanran Mai; Li Huang; Di Che; Jianping Tao; Xiaoqiong Gu

doi:10.2147/JIR.S281760

LncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children

J Inflamm Res. 2020 Dec 10:13:1095-1101. doi: 10.2147/JIR.S281760. eCollection 2020.

Authors

Zhiyuan Wu^#¹, Yongqin Yu^#¹, Lanyan Fu², Hanran Mai², Li Huang¹, Di Che², Jianping Tao¹, Xiaoqiong Gu^{2

3

4}

Affiliations

¹ Department of Pediatric Intensive Care Unit, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, People's Republic of China.
² Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, People's Republic of China.
³ Department of Blood Transfusion, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, People's Republic of China.
⁴ Department of Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, People's Republic of China.

^# Contributed equally.

Abstract

Background: Sepsis in children is one of the main causes of death in pediatric intensive care units (PICUs); however, the pathogenesis of sepsis is not fully clear. Previous studies revealed that many genetic variations were related to sepsis susceptibility. A long non-coding RNA SOX2 overlapping transcript (SOX2OT) may play a role in mitochondrial homeostasis and antioxidative activity, but the relationship between the lncRNA SOX2OT polymorphism and sepsis susceptibility has not been reported.

Methods: In this study, 474 pediatric sepsis patients and 678 healthy controls were recruited from southern China. After genotyping, the strength of the associations was evaluated through odds ratios (ORs) and 95% confidence intervals (CIs).

Results: The SOX2OT rs9839776 T allele was associated with decreased susceptibility to sepsis in southern Chinese children (TT/CT vs CC adjusted OR = 0.778, 95% CI = 0.610-0.992; P = 0.0431). Moreover, the difference in susceptibility was greater in children of age >60 months (adjusted OR = 0.458, 95% CI = 0.234-0.896; P = 0.0225), survivors (adjusted OR = 0.758, 95% CI = 0.585-0.972; P = 0.0358), males (adjusted OR = 0.655, 95% CI = 0.479-0.894; P = 0.0077) and the sepsis subgroup (adjusted OR = 0.548, 95% CI = 0.343-0.876; P = 0.0120).

Conclusion: The rs9839776 T allele may contribute to decreased sepsis risk in Chinese children. Future studies with a larger sample size are needed to verify these results.

Keywords: SOX2OT; polymorphism; rs9839776; sepsis; susceptibility.

Grants and funding

This study was funded by the Guangdong Provincial Science and Technology Plan (China, 2017A030223003), Guangzhou Medical and Health Technology Projects (China, 20191A011033 and 20191A011021), Guangzhou Science and Technology Program Key Projects (China, 201904010486 and 201804010035), Guangdong Natural Science Foundation (China, 2019A1515012061), and Guangzhou Institute of Pediatrics/Guangzhou Women and Children’s Medical Center Fund (China, grant number YIP-2018-019, GCP-2019-003, YIP-2019-050, GCP-2019-006).