Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19

Karel F A Van Damme; Simon Tavernier; Nele Van Roy; Elisabeth De Leeuw; Jozefien Declercq; Cédric Bosteels; Bastiaan Maes; Marieke De Bruyne; Delfien Bogaert; Victor Bosteels; Levi Hoste; Leslie Naesens; Piet Maes; Alba Grifoni; Daniela Weiskopf; Alessandro Sette; Pieter Depuydt; Eva Van Braeckel; Filomeen Haerynck; Bart N Lambrecht

doi:10.3389/fimmu.2020.596761

Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19

Front Immunol. 2020 Nov 20:11:596761. doi: 10.3389/fimmu.2020.596761. eCollection 2020.

Authors

Karel F A Van Damme^{1

2}, Simon Tavernier^{1

3}, Nele Van Roy¹, Elisabeth De Leeuw^{1

2}, Jozefien Declercq^{1

2}, Cédric Bosteels^{1

2}, Bastiaan Maes^{1

2}, Marieke De Bruyne⁴, Delfien Bogaert^{1

5}, Victor Bosteels^{1

6}, Levi Hoste^{1

5}, Leslie Naesens^{1

5}, Piet Maes⁷, Alba Grifoni⁸, Daniela Weiskopf⁸, Alessandro Sette^{8

9}, Pieter Depuydt^{1

10}, Eva Van Braeckel^{1

11}, Filomeen Haerynck^{1

5}, Bart N Lambrecht^{1

2

11

12}

Affiliations

¹ Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
² Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
³ Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
⁴ Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.
⁵ Primary Immunodeficiency Research Lab, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium.
⁶ Laboratory of ER Stress and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
⁷ Department of Microbiology, Immunology, and Transplantation, Rega Institute for Medical Research, Division of Clinical and Epidemiological Virology, KU Leuven, Leuven, Belgium.
⁸ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
⁹ Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), CA, United States.
¹⁰ Department of Intensive Care, Ghent University Hospital, Ghent, Belgium.
¹¹ Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
¹² Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands.

Abstract

The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient's condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding.

Keywords: COVID-19; case report; common variable immunodeficiency disorders; convalescent plasma; immunodeficiencies.

Copyright © 2020 Van Damme, Tavernier, Van Roy, De Leeuw, Declercq, Bosteels, Maes, De Bruyne, Bogaert, Bosteels, Hoste, Naesens, Maes, Grifoni, Weiskopf, Sette, Depuydt, Van Braeckel, Haerynck and Lambrecht.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antibodies, Viral / administration & dosage*
COVID-19 / blood
COVID-19 / immunology
COVID-19 / therapy*
COVID-19 Serotherapy
Common Variable Immunodeficiency* / blood
Common Variable Immunodeficiency* / immunology
Common Variable Immunodeficiency* / therapy
Humans
Immunization, Passive
Male
RNA, Viral* / blood
RNA, Viral* / immunology
SARS-CoV-2* / immunology
SARS-CoV-2* / metabolism
Virus Shedding* / drug effects
Virus Shedding* / immunology

Substances

Antibodies, Viral
RNA, Viral