An assessment of the effects of internal neurolysis on a chronically compressed rat sciatic nerve

Plast Reconstr Surg. 1988 Feb;81(2):251-8. doi: 10.1097/00006534-198802000-00020.

Abstract

Chronically compressed nerves were treated with three surgical modalities. Simple decompression was compared to internal neurolysis with and without the addition of extrafascicular steroid. Electrophysiologic, histologic, and morphometric assessments were performed. Compressed control nerves demonstrated changes compatible with severe nerve compression (Wallerian degeneration). With simple decompression, improvement in histologic and electrophysiologic parameters occurred. When internal neurolysis was added to the decompression, further improvement in histologic and electrophysiologic parameters was noted. There was no added improvement with the addition of steroids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dexamethasone / pharmacology
  • Disease Models, Animal
  • Male
  • Nerve Compression Syndromes / pathology
  • Nerve Compression Syndromes / physiopathology
  • Nerve Compression Syndromes / surgery*
  • Neural Conduction
  • Rats
  • Rats, Inbred Strains
  • Sciatic Nerve / drug effects
  • Sciatic Nerve / pathology
  • Sciatic Nerve / surgery*

Substances

  • Dexamethasone