Emergence and Recovery of Ceftazidime-avibactam Resistance in blaKPC-33-Harboring Klebsiella pneumoniae Sequence Type 11 Isolates in China

Qingyu Shi; Dandan Yin; Renru Han; Yan Guo; Yonggui Zheng; Shi Wu; Yang Yang; Shirong Li; Rong Zhang; Fupin Hu

doi:10.1093/cid/ciaa1521

Emergence and Recovery of Ceftazidime-avibactam Resistance in blaKPC-33-Harboring Klebsiella pneumoniae Sequence Type 11 Isolates in China

Clin Infect Dis. 2020 Dec 23;71(Suppl 4):S436-S439. doi: 10.1093/cid/ciaa1521.

Authors

Qingyu Shi^{1

2}, Dandan Yin^{1

2}, Renru Han^{1

2}, Yan Guo^{1

2}, Yonggui Zheng^{1

2}, Shi Wu^{1

2}, Yang Yang^{1

2}, Shirong Li³, Rong Zhang⁴, Fupin Hu^{1

2}

Affiliations

¹ Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
² Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
³ Laboratory Medicine, Huashan Hospital (West campus), Fudan University, Shanghai, China.
⁴ Department of Clinical Laboratory Medicine, Second Affiliated Hospital of Zhejiang University, Hangzhou, China.

PMID: 33367577
DOI: 10.1093/cid/ciaa1521

Abstract

This is the first report of ceftazidime-avibactam resistance caused by the blaKPC-33 mutation through the D179Y variant during the treatment of blaKPC-2-positive Klebsiella pneumoniae-related infections in China. The blaKPC-33-containing K. pneumoniae was susceptible to meropenem-vaborbactam, cefepime-zidebactam, tigecycline, and polymyxin B. The blaKPC-33 gene was located on a 77 551-bp transformable plasmid harboring qnrS1 and blaLAP-2. Detecting blaKPC-33-positive K. pneumoniae clinical strains is important for infection control.

Keywords: bla KPC-2; bla KPC-33; Carbapenem-resistant K. pneumoniae; Ceftazidime-avibactam; Meropenem-vaborbactam.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Azabicyclo Compounds / pharmacology
Bacterial Proteins / genetics
Ceftazidime
China
Drug Combinations
Humans
Klebsiella Infections* / epidemiology
Klebsiella pneumoniae* / genetics
Microbial Sensitivity Tests
beta-Lactamases / genetics

Substances

Anti-Bacterial Agents
Azabicyclo Compounds
Bacterial Proteins
Drug Combinations
avibactam, ceftazidime drug combination
Ceftazidime
beta-Lactamases