JAK2/CALR/SF3B1 triple-mutated myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis evolving to myelofibrosis and SF3B1 single-mutated acute myeloid leukemia: Evidence of a pre-JAK2 clone

Leuk Res. 2021 Jan:100:106496. doi: 10.1016/j.leukres.2020.106496. Epub 2020 Dec 15.

Authors

Hajime Yasuda¹, Soji Morishita², Yosuke Mori³, Yutaka Tsukune³, Tadaaki Inano³, Sakiko Harada³, Norio Komatsu³

Affiliations

¹ Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: [email protected].
² Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University School of Medicine, Tokyo, Japan.
³ Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan.

PMID: 33373831
DOI: 10.1016/j.leukres.2020.106496

No abstract available

Keywords: Essential thrombocythemia; KIT; MDS/MPN-RS-T; RARS-T; TET2.

Publication types

Case Reports
Letter

MeSH terms

Calreticulin / genetics
Erythroblasts / pathology*
Humans
Janus Kinase 2 / genetics*
Leukemia, Myeloid, Acute / etiology
Leukemia, Myeloid, Acute / pathology*
Male
Middle Aged
Mutation*
Myelodysplastic-Myeloproliferative Diseases / complications*
Myelodysplastic-Myeloproliferative Diseases / genetics
Phosphoproteins / genetics
Primary Myelofibrosis / etiology
Primary Myelofibrosis / pathology*
Prognosis
RNA Splicing Factors / genetics
Thrombocytosis / complications*
Thrombocytosis / genetics

Substances

CALR protein, human
Calreticulin
Phosphoproteins
RNA Splicing Factors
SF3B1 protein, human
JAK2 protein, human
Janus Kinase 2