Mitochondrial bioenergetics in leukocytes and oxidative stress in blood serum of mild to moderately depressed women

Anja M Gumpp; Alexander Behnke; Alexandra M Bach; Sophia Piller; Christina Boeck; Roberto Rojas; Iris-Tatjana Kolassa

doi:10.1016/j.mito.2020.12.009

Mitochondrial bioenergetics in leukocytes and oxidative stress in blood serum of mild to moderately depressed women

Mitochondrion. 2021 May:58:14-23. doi: 10.1016/j.mito.2020.12.009. Epub 2020 Dec 28.

Authors

Anja M Gumpp¹, Alexander Behnke², Alexandra M Bach³, Sophia Piller⁴, Christina Boeck⁵, Roberto Rojas⁶, Iris-Tatjana Kolassa⁷

Affiliations

¹ Clinical & Biological Psychology, Institute of Psychology and Education, Ulm, University, Albert-Einstein-Allee 47, DE-89081 Ulm, Germany. Electronic address: [email protected].
² Clinical & Biological Psychology, Institute of Psychology and Education, Ulm, University, Albert-Einstein-Allee 47, DE-89081 Ulm, Germany. Electronic address: [email protected].
³ Clinical & Biological Psychology, Institute of Psychology and Education, Ulm, University, Albert-Einstein-Allee 47, DE-89081 Ulm, Germany. Electronic address: [email protected].
⁴ Clinical & Biological Psychology, Institute of Psychology and Education, Ulm, University, Albert-Einstein-Allee 47, DE-89081 Ulm, Germany. Electronic address: [email protected].
⁵ Clinical & Biological Psychology, Institute of Psychology and Education, Ulm, University, Albert-Einstein-Allee 47, DE-89081 Ulm, Germany. Electronic address: [email protected].
⁶ University Psychotherapeutic Outpatient Clinic, Institute of Psychology and Education, Ulm University, Schaffnerstr. 3, DE-89073 Ulm, Germany. Electronic address: [email protected].
⁷ Clinical & Biological Psychology, Institute of Psychology and Education, Ulm, University, Albert-Einstein-Allee 47, DE-89081 Ulm, Germany. Electronic address: [email protected].

PMID: 33383159
DOI: 10.1016/j.mito.2020.12.009

Abstract

Major depressive disorder (MDD) has been associated with lower mitochondrial energy production and higher oxidative stress. We investigated whether these alterations manifest in patients with current mild to moderate MDD severity. We observed no differences in mitochondrial respiration and density (i.e., citrate-synthase activity) in peripheral blood mononuclear cells and oxidative stress markers (i.e., 8-hydroxy-2'-deoxyguanosine, 8-isoprostane) in blood serum of 20 female MDD patients compared to 24 non-depressed women. Alterations in mitochondrial energy production and oxidative stress did not linearly depend on the current severity of MDD. However, biological alterations might rather manifest with higher MDD severity/chronicity and at higher age.

Keywords: Citrate-synthase activity; Major depressive disorder; Mitochondrial bioenergetics; Oxidative stress; PBMC; Respirometry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Depressive Disorder, Major / blood*
Energy Metabolism*
Female
Humans
Leukocytes / metabolism*
Middle Aged
Mitochondria / metabolism*
Oxidative Stress*
Severity of Illness Index
Young Adult