We report a case of multidrug-resistant Pseudomonas aeruginosa meningitis treated with ceftolozane-tazobactam with concomitant therapeutic drug monitoring of plasma and cerebral spinal fluid. The data suggest that ceftolozane-tazobactam may be an option for select central nervous system infections; however, treatment decisions should be interpreted on a case-by-case basis.
Keywords: central nervous system; difficult-to-treat; gram-negative; beta-lactamase inhibitor.
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.