Growth Competition in Interspecies Chimeras: A New Paradigm for Blastocyst Complementation

Emily B Ballard; Jun Wu

doi:10.1016/j.stem.2020.12.011

Growth Competition in Interspecies Chimeras: A New Paradigm for Blastocyst Complementation

Cell Stem Cell. 2021 Jan 7;28(1):3-5. doi: 10.1016/j.stem.2020.12.011.

Authors

Emily B Ballard¹, Jun Wu²

Affiliations

¹ Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: [email protected].

PMID: 33417870
DOI: 10.1016/j.stem.2020.12.011

Abstract

Blastocyst complementation represents a powerful technique for interspecies organogenesis but is limited by low chimerism due to developmental incompatibilities. In this issue of Cell Stem Cell,Nishimura et al. (2021) circumvent early developmental barriers by disabling Igf1r in host embryos, conferring donor cells with a growth advantage from mid-gestation onward.

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MeSH terms

Animals
Blastocyst
Chimera*
Organogenesis
Pluripotent Stem Cells*
Rodentia