Stem cell origins of JMML

J Exp Med. 2021 Feb 1;218(2):e20202152. doi: 10.1084/jem.20202152.

Abstract

In this issue of JEM, Louka et al. (https://doi.org/10.1084/jem.20180853) report that leukemia stem cells lie within the phenotypic hematopoietic stem cell and progenitor cell compartments in juvenile myelomonocytic leukemia (JMML). Furthermore, they identify several candidate biomarker/therapeutic targets, such as CD96 and SLC2A1, that are of translational significance in JMML.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Hematopoietic Stem Cells
  • Humans
  • Leukemia, Myelomonocytic, Juvenile*