Hypoxia: Uncharged tRNA to the Rescue!

Thomas E Mulroney; Tuija Pöyry; Anne E Willis

doi:10.1016/j.cub.2020.10.067

Hypoxia: Uncharged tRNA to the Rescue!

Curr Biol. 2021 Jan 11;31(1):R25-R27. doi: 10.1016/j.cub.2020.10.067.

Authors

Thomas E Mulroney¹, Tuija Pöyry², Anne E Willis³

Affiliations

¹ MRC Toxicology Unit, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QW, UK. Electronic address: [email protected].
² MRC Toxicology Unit, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QW, UK.
³ MRC Toxicology Unit, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QW, UK. Electronic address: [email protected].

PMID: 33434482
DOI: 10.1016/j.cub.2020.10.067

Abstract

A new study has identified genes that protect Caenorhabditis elegans from hypoxic stress. Genomic approaches and whole-organism proteomics reveal a regulatory interaction between a threonyl-tRNA synthetase and ribosome biogenesis that modulates global translation and hypoxic sensitivity.

Publication types

Editorial
Comment

MeSH terms

Amino Acyl-tRNA Synthetases* / genetics
Animals
Caenorhabditis elegans / genetics
Hypoxia / genetics
RNA, Transfer / genetics
Threonine-tRNA Ligase*

Substances

RNA, Transfer
Amino Acyl-tRNA Synthetases
Threonine-tRNA Ligase

Abstract

Publication types

MeSH terms

Substances

Grants and funding