The Intestinal Microbiota: Our Best Frenemy in Radiation-Induced Damages?

Melissa C Kordahi; Benoit Chassaing

doi:10.1016/j.chom.2020.12.013

The Intestinal Microbiota: Our Best Frenemy in Radiation-Induced Damages?

Cell Host Microbe. 2021 Jan 13;29(1):7-9. doi: 10.1016/j.chom.2020.12.013.

Authors

Melissa C Kordahi¹, Benoit Chassaing²

Affiliations

¹ INSERM U1016, team ''Mucosal microbiota in chronic inflammatory diseases'', CNRS UMR 8104, Université de Paris, Paris, France.
² INSERM U1016, team ''Mucosal microbiota in chronic inflammatory diseases'', CNRS UMR 8104, Université de Paris, Paris, France. Electronic address: [email protected].

PMID: 33444556
DOI: 10.1016/j.chom.2020.12.013

Abstract

High-dose ionizing radiation used during cancer radiotherapy is associated with the induction of hematopoietic, gastrointestinal, and cerebrovascular injuries. In a recent Science issue, Guo et al. demonstrated that the gut microbiota-and its associated metabolites-play a central role in protecting against high-dose radiation.

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MeSH terms

Gastrointestinal Microbiome*
Gastrointestinal Tract
Humans
Radiation*
Survivors