Musculin is highly enriched in Th17 and IL-22-producing ILC3s and restrains pro-inflammatory cytokines in murine colitis

Eur J Immunol. 2021 Apr;51(4):995-998. doi: 10.1002/eji.202048573. Epub 2021 Feb 2.

Abstract

Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC+/+ mice survived DSS-induced colitis, MSC-/- mice showed elevated pro-inflammatory cytokines with severer pathology, reduced body weight, and earlier death. Reversal of colitis symptoms in MSC-/- mice by IL-22 antagonism suggests the existence of MSC:IL-22 regulatory axis.

Keywords: IL-22; ILC3; Musculin; Th17; Transcription factor.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / immunology*
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • Colitis / chemically induced
  • Colitis / genetics
  • Colitis / immunology*
  • Cytokines / immunology*
  • Cytokines / metabolism
  • Dextran Sulfate
  • Immunity, Innate / immunology
  • Inflammation Mediators / immunology*
  • Inflammation Mediators / metabolism
  • Interleukin-17 / immunology
  • Interleukin-17 / metabolism
  • Interleukin-22
  • Interleukins / genetics
  • Interleukins / immunology*
  • Interleukins / metabolism
  • Lymphocytes / immunology*
  • Lymphocytes / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Th17 Cells / immunology*
  • Th17 Cells / metabolism

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Cytokines
  • Inflammation Mediators
  • Interleukin-17
  • Interleukins
  • Msc protein, mouse
  • Dextran Sulfate