HLA-A*11:382N, a novel HLA-A null allele identified by next-generation sequencing

HLA. 2021 May;97(5):448-449. doi: 10.1111/tan.14185. Epub 2021 Jan 21.

Authors

Valery Cheranev¹, Maria Loginova², Tatjana Jankevic¹, Denis Rebrikov¹, Dmitriy Korostin¹

Affiliations

¹ Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Medical University, Moscow, Russia.
² The Research Laboratory of Applied Immunogenetics, Federal State Budget Research Institution: Kirov Hematology and Blood Transfusion Research Institute under the Federal Medicine and Biology Agency, Kirov, Russia.

PMID: 33448684
DOI: 10.1111/tan.14185

Abstract

The new allele HLA-A*11:382N showed one nucleotide difference with HLA-A*11:01:01:01 at codon 254 (nonsense mutation).

Keywords: HLA-A*11:382N; NGS HLA typing; null allele.

© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Codon
Codon, Nonsense*
HLA-A Antigens / genetics
High-Throughput Nucleotide Sequencing*
Histocompatibility Testing
Humans
Sequence Analysis, DNA

Substances

Codon
Codon, Nonsense
HLA-A Antigens