Description of a late miscarriage case at 16 Weeks of Gestation associated with a SARS-CoV-2 infection

J Gynecol Obstet Hum Reprod. 2021 Mar;50(3):102064. doi: 10.1016/j.jogoh.2021.102064. Epub 2021 Jan 13.

Abstract

Background: Data about obstetric complications of maternal infection by SARS-CoV-2 remain sparse.

Case: A 40-year-old pregnant woman, gravida 3 para 1 with no previous obstetric complications, presented a late miscarriage at 16 weeks of gestation on day 9 of COVID-19 disease. The results of her nasopharyngeal swab for SARS-CoV-2, tested the same day, were negative, but the placenta was infected by SARS-CoV-2 and serology was positive 11 days later. No other obstetric or infectious cause was found to explain this outcome.

Conclusion: This case strongly suggests that SARS-CoV-2 may lead to a late miscarriage.

Keywords: Late miscarriage; Obstetric outcomes; Placental colonization; SARS-CoV-2.

Publication types

  • Case Reports

MeSH terms

  • Abortion, Spontaneous / virology*
  • Adult
  • COVID-19 / complications*
  • COVID-19 / diagnosis
  • COVID-19 Serological Testing
  • COVID-19 Testing / methods
  • Female
  • Fetus / virology
  • Gestational Age
  • Humans
  • Placenta / virology
  • Pregnancy
  • Pregnancy Complications, Infectious / virology*
  • Real-Time Polymerase Chain Reaction
  • SARS-CoV-2* / genetics
  • SARS-CoV-2* / immunology
  • SARS-CoV-2* / isolation & purification