Dynamic evolution of ponatinib-resistant mutations in BCR-ABL1-positive leukaemias revealed by next-generation sequencing

Br J Haematol. 2020 Dec;191(5):e113-e116. doi: 10.1111/bjh.17068. Epub 2020 Sep 10.
No abstract available

Keywords: BCR‐ABL1; compound mutations; drug‐resistant mutation; next‐generation sequencing; tyrosine kinase inhibitors.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Child
  • Drug Resistance, Neoplasm / genetics*
  • Female
  • Fusion Proteins, bcr-abl / genetics*
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Imidazoles / administration & dosage*
  • Leukemia / drug therapy*
  • Leukemia / genetics*
  • Male
  • Middle Aged
  • Mutation*
  • Pyridazines / administration & dosage*

Substances

  • BCR-ABL1 fusion protein, human
  • Imidazoles
  • Pyridazines
  • ponatinib
  • Fusion Proteins, bcr-abl