NAFLD Cirrhosis Is Rising Among Childbearing Women and Is the Most Common Cause of Cirrhosis in Pregnancy

Monika Sarkar; Maya Djerboua; Jennifer A Flemming

doi:10.1016/j.cgh.2021.01.022

NAFLD Cirrhosis Is Rising Among Childbearing Women and Is the Most Common Cause of Cirrhosis in Pregnancy

Clin Gastroenterol Hepatol. 2022 Feb;20(2):e315-e318. doi: 10.1016/j.cgh.2021.01.022. Epub 2021 Jan 16.

Authors

Monika Sarkar¹, Maya Djerboua², Jennifer A Flemming³

Affiliations

¹ Division of Gastroenterology and Hepatology, University of California, San Francisco, San Francisco, California. Electronic address: [email protected].
² ICES, Queen's University, Kingston, Ontario, Canada.
³ ICES, Queen's University, Kingston, Ontario, Canada; Division of Gastroenterology and Hepatology, Queen's University, Kingston, Ontario, Canada.

PMID: 33465483
DOI: 10.1016/j.cgh.2021.01.022

Abstract

Rates of pregnancies affected by nonalcoholic fatty liver disease (NAFLD) in the United States have nearly tripled in the last decade and NAFLD confers increased perinatal risks, such as hypertensive complications, postpartum hemorrhage, and preterm birth.¹ Rates of cirrhosis in pregnancy are also rising,² although estimates specific to NAFLD cirrhosis are lacking. Whether NAFLD cirrhosis confers differential perinatal risks than other causes of cirrhosis in pregnancy is also unknown.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Female
Fibrosis
Humans
Infant, Newborn
Liver Cirrhosis / complications
Non-alcoholic Fatty Liver Disease* / complications
Non-alcoholic Fatty Liver Disease* / epidemiology
Pregnancy
Premature Birth*
United States / epidemiology