[AFP and PIVKA-Ⅱ Producing Gastric Cancer with Metachronous Liver Metastasis after Gastrectomy-A Case Report]

Gan To Kagaku Ryoho. 2020 Dec;47(13):2156-2158.
[Article in Japanese]

Abstract

A 67-year-old man visited his doctor because of anorexia and was diagnosed with gastric cancer based on endoscopic findings. Endoscopy revealed a 0-Ⅰ type tumor, 6 cm in size, at the gastric angle. Preoperative CT showed no apparent lymph node or distant metastases. Distal gastrectomy was performed for gastric cancer with Billroth Ⅰ reconstruction. He had no complications and was discharged on postoperative day 11. The pathological Stage was pT2N0M0, pStage ⅠB, and he underwent no adjuvant chemotherapy. Four months postoperatively, serum CA19-9, AFP, and PIVKA-Ⅱ were elevated, and CT revealed multiple liver tumors. A liver biopsy was performed for the definitive diagnosis. The patient was diagnosed with liver metastases from gastric cancer. It is considered that AFP and PIVKA-Ⅱ were produced by the liver metastasis from gastric cancer. He received chemotherapy for liver metastasis and died 1 year after the recurrence.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biomarkers
  • Gastrectomy
  • Humans
  • Liver Neoplasms* / drug therapy
  • Liver Neoplasms* / surgery
  • Male
  • Neoplasm Recurrence, Local
  • Protein Precursors
  • Prothrombin
  • Stomach Neoplasms* / drug therapy
  • Stomach Neoplasms* / surgery
  • alpha-Fetoproteins

Substances

  • Biomarkers
  • Protein Precursors
  • alpha-Fetoproteins
  • acarboxyprothrombin
  • Prothrombin