Structural recirculation and refractory hypoxemia under femoro-jugular veno-venous extracorporeal membrane oxygenation

The performance of each veno-venous extracorporeal membrane oxygenation (vv-ECMO) configuration is determined by the anatomic context and cannula position. A mathematical model was built considering bicaval specificities to simulate femoro-jugular configuration. The main parameters to define were cardiac output (Q_C ), blood flow in the superior vena cava (Q_SVC ), extracorporeal pump flow (Q_EC ), and pulmonary shunt (k_S-PULM ). The obtained variables were extracorporeal flow ratio in the superior vena cava (EFR_SVC = Q_EC /[Q_EC + Q_SVC ]), recirculation coefficient (R), effective extracorporeal pump flow (Q_eff-EC = [1 - R] × Q_EC ), Q_eff-EC /Q_C ratio, and arterial blood oxygen saturation (SaO₂ ). EFR_SVC increased logarithmically when Q_EC increased. High Q_C or high Q_SVC /Q_C decreased EFR_SVC (range, 68%-85% for Q_EC of 5 L/min). R also increased following a logarithmic shape when Q_EC increased. The R rise was earlier and higher for low Q_C and high Q_SVC /Q_C (range, 12%-49% for Q_EC of 5 L/min). The Q_eff-EC /Q_C ratio (between 0 and 1) was equal to EFR_SVC for moderate and high Q_EC . The Q_eff-EC /Q_C ratio presented the same logarithmic profile when Q_EC increased, reaching a plateau (range, 0.67-0.91 for Q_EC /Q_C = 1; range, 0.75-0.94 for Q_EC /Q_C = 1.5). The Q_eff-EC /Q_C ratio was linearly associated with SaO₂ for a given pulmonary shunt. SaO₂ < 90% was observed when the pulmonary shunt was high (Q_eff-EC /Q_C ≤ 0.7 with k_S-PULM = 0.7 or Q_eff-EC /Q_C ≤ 0.8 with k_S-PULM = 0.8). Femoro-jugular vv-ECMO generates a systematic structural recirculation that gradually increases with Q_EC . EFR_SVC determines the Q_eff-EC /Q_C ratio, and thereby oxygen delivery and the superior cava shunt. EFR_SVC cannot exceed a limit value, explaining refractory hypoxemia in extreme situations.