Antipsychotic medication is the primary treatment for schizophrenia, which is effective on ameliorating positive symptoms and can reduce the risk of recurrence, but it has limited efficacy for negative symptoms and cognitive dysfunction. The negative symptoms and cognitive dysfunction seriously affects the life quality and social function for the patients with schizophrenia. Currently, there is plenty evidence that antipsychotic drugs combined with adjuvant therapy drugs can effectively improve the negative symptoms and cognitive dysfunction. These drugs include anti-oxidants, nicotinic acetylcholine receptors and neuro-inflammatory drugs (anti-inflammatory drugs, minocycline), which show potential clinical effects.
抗精神病药物是治疗精神分裂症的主要方法，可有效缓解阳性症状和减少复发风险，但对阴性症状和认知功能障碍的临床疗效有限，而阴性症状和认知功能障碍严重影响精神分裂症患者的社会功能和生活质量。目前有较多的研究支持抗精神病药物联合辅助治疗药物可有效改善阴性症状和认知功能障碍。其中，作用于氧化应激、烟碱能乙酰胆碱受体和神经炎症的药物(抗炎药、米诺环素)有潜在的临床疗效。.
Keywords: add-on treatment; cognitive dysfunction; negative symptoms; schizophrenia.